Positive Effect of Settle® on Postpartum Involution Published in the Journal of Equine Veterinary Science

21 April 2020

Napanee, Ontario, Canada – NovaVive Inc., an animal health immunobiology company, announces that data from a study with its immunotherapy for the treatment of equine endometritis – Settle® - has been published in the Journal of Equine Veterinary Science (JEVS). The article, “The effect of mycobacterium cell wall fraction on histological, immunological, and clinical parameters of postpartum involution in the mare”, was authored by C.E. Fedorka, H. Murase, S.C. Loux, A.T. Loynachan, O.F. Walker, E.L. Squires, B.A. Ball and M.H.T. Troedsson. All the authors are from the Department of Veterinary Sciences, University of Kentucky, Lexington, KY, USA.

The data summarized in the JEVS article were generated from a study assessing the effect of Settle on histological involution, cell-mediated immunity of the uterus, and clinical endpoints associated with involution.

Uterine involution is a natural occurrence in the postpartum mare, characterized by expulsion of fetal membranes and contraction of the uterus, cervix and broad ligaments. For maximum reproductive efficiency and economic success, a broodmare must produce a foal every year. To retain this schedule, the mare must be bred at the earliest opportunity postpartum, ideally at the “foal heat” (first postpartum estrus). If uterine involution occurs efficiently, foal heat breeding is more likely to be successful.

In this study, 16 postpartum mares were divided into three treatment groups. Treatments in all mares began one day after parturition. Group 1 received two doses of Settle, one week apart, by IV injection; group 2 received one IV dose of Settle every three days until ovulation was detected; and group 3 received two IV doses of lactated Ringers solution, one week apart. The mares’ reproductive tracts were assessed every 72 hours and cytology and bacterial cultures were undertaken.

The authors stated that this is the first study to evaluate the effect of involution on cytokine expression, and inflammation was predominantly complete within 10 days postpartum. They added that the use of immunomodulation may hasten this process, as it increases the expression of pro-inflammatory cytokines, decreases the time to bacterial clearance, and may also lower the amount of mucosal inflammation noted. The authors concluded that Settle be administered in a two-dose series for maximum effect - one day and 8 days postpartum – to assist with the elimination of bacteria that may impede future fertility on the foal heat estrus cycle.

In another clinical study (Fumuso et al. 2003), mares bred at foal heat and treated with Settle had a 65% pregnancy rate as compared to a 24% pregnancy rate for mares bred at foal heat and treated with a placebo.

Settle is manufactured using the NovaVive Mycobacterium cell wall fraction (MCWF) technology. It is approved in the USA, Australia and New Zealand as an aid in the treatment of equine endometritis caused by Streptococcus zooepidemicus, the hardest to treat cause of the disease. When administered by IV injection or intrauterine (IU) infusion, Settle stimulates the mare’s immune system to fight the infection.

About NovaVive Inc.

NovaVive is a private company founded in July, 2014. The Company has an advanced veterinary immunotherapeutic platform based on mycobacterium cell wall fraction (MCWF) technology with 5 regulator-approved products in the USA. One formulation has been developed as an anticancer therapy in dogs and horses. Other formulations have demonstrated the capability of reducing the reliance on antibiotics in the treatment of bacterial diseases of horses and cattle or effectively treating viral equine respiratory disease. The Company’s development plan is to identify additional livestock and companion animal diseases that may be effectively treated with its immunotherapeutic technology platform. For more information about the Company, please visit www.NovaVive.ca, or contact:

Graeme McRae                                                  
Phone: 613-391-3837


Jennifer Shea

Phone: 613-391-2097

Sign up to stay up-to-date with NovaVive news.